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Role of Glutathione in Human Diseases Glutathione plays a pivotal role in physiological processes, including the maintenance of redox balance, neutralizing oxidative stress by promoting the metabolic detoxification of both xenobiotic and endogenous compounds, and regulating the function of the immune system [14]

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Similarly, Insulin-like growth factor 1 hair cell protection from neomycin damage is lost by inhibition of Akt or MEK signaling, suggesting that growth factor otoprotection may operate on a similar set of downstream targets (Hayashi et al., 2003