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The first large, controlled trial included 251 patients with an EDSS score between 0 and 5.5 and at least two relapses in the preceding 2 years, randomized to receive either placebo or 20 mg glatiramer acetate subcutaneous daily for up to 3 years (53)

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Rather than focusing on short-term anecdotes, serious investigators try to map which pathways appear most responsive, what concentrations are relevant in their models, and how repeatable those findings are in different systems

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