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Recent clinical studies using 1 H-MRS showed that GSH levels in the brains of ALS patients were decreased compared to those of age-matched healthy volunteers [111], and the decreased GSH levels in the motor cortex and corticospinal tract were inversely correlated with the time after diagnosis [112]

Analysis of the top 20 enriched pathways by KEGG revealed that cellular functions such as the NF-kappa B signaling pathway (ko04064), antigen processing and presentation (ko04612), and Th17 cell differentiation (ko04659) were inhibited after immunotherapy, which further confirmed that the fraction of Th17 cells was significantly reduced in PT patients

[DOI] [PubMed] [Google Scholar] 124.Splendiani A., Perri M., Marsecano C., Vellucci V., Michelini G., Barile A., Di Cesare E

In: Pitknen A, Buckmaster PS, Galanopoulou AS et al (eds) Models of seizures and epilepsy
