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An increase in ROS accelerates tumor cell death, while GSH, as a key component in redox homeostasis, plays a crucial role in scavenging ROS and neutralizing exogenous metabolites in tumor cells [15]

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AOD9604 (Anti-Obesity Drug 9604) is a synthetic peptide fragment corresponding to amino acids 177-191 of human growth hormone (hGH), with the addition of a tyrosine residue at the N-terminus

To construct the pPapi-SLC25 library, SpCas9 and SaCas9 guides were designed to target 53 SLC25 carriers, seven additional SLC proteins present in MitoCarta 2.0 16 , BCL2L1, MCL1 (the two paralogous anti-apoptotic proteins) and EEF2 (elongation factor 2, essential for protein translation) as positive controls, 8 non-cutting controls and 19 cutting controls that target olfactory receptors (ORs) as negative controls