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The injury can be either acute (one-time mechanism) or chronic (gradual inflammation caused by repetitive injury)

Seeding Propensity and Characteristics of Pathogenic Syn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease

doi: 10.1016/j.transproceed.2010.02.097

Rescue arms Predefined component of a trial designed to allow participants who have not responded or cannot tolerate the assigned treatment to be offered an alternative treatment or intervention (typically, allows participants randomized to placebo to end participation in a blinded component of the trial and receive the investigational product open-label)