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Tumor cells form a two-way connection with circumferent stroma in the early stage of invasion and after that, tumor-stroma interaction helps the tumor to develop toward metastasis ( Pre-Metastatic Niche An appropriate microenvironment, namely, pre-metastatic niche, can be established in secondary tissues and organs before metastases occurring through a complicated mechanism by interaction between the primary tumors and organs stromal components (92)

4.2 Energy Metabolism Energy is defined as the capacity to do work (Wu 2018)

Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses

Male subjects were required to weigh 50.0 kg, and female subjects 45.0 kg, with a body mass index (BMI) ranging from 19.0 to 26.0 kg/m