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Funding Statement The authors are supported by research grants of the German Academic Exchange Service (DAAD) and the Government of Ghana (to P.D.-N.), Deutsche Forschungsgemeinschaft (DFG) (Grants MO 1695/4-1 and 5-1

Figure 1 2.1.4 Bile acids (BAs) as modulators in Alzheimer's brain-gut axis A potential therapeutic approach for AD consists of the BAs, which are produced in the liver (Monteiro-Cardoso et al., 2021)

Read review Dihexa for Autism Spectrum Disorder (ASD) The Campbell rs1858830 MET promoter C-allele autism finding (the strongest mechanistic anchor to Dihexa pharmacology), the January 2026 mGluR5 PET 16-23% lower availability, the December 2025 DAYBUE STIX (trofinetide) Rett approval, the March 2026 FDA leucovorin decision (CFD only, not autism), the 270,701 NHS open referrals breaching NICE NG142, and the ~700,000 UK autistic population