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found that colivelin, a synthetic derivative of the mitochondrial peptide humanin, reduces the plasma syndecan-1, tumor necrosis factor- (TNF-), and interleukin-10 (IL-10) concentrations

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In a study of 581 moderate-severe psoriasis patients, an increased prevalence was found for metabolic syndrome (OR=5.29), psoriasis patients were more likely to have diabetes mellitus, hypertension, hyperlipidemia, coronary heart disease and they were also more likely to be smokers [48]