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Other malignancies, including urinary tract, stomach, and small intestine cancers, have also been linked to MSH6 mutations, though they occur less frequently ( 2.1.3 PMS1 homolog 2 ( PMS2 ) A defective PMS2 gene associated with LS substantially elevates the possibilities of developing specific cancers, particularly CRC and EC in comparison to the general population

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The absence of dendritic cells in MucilAir-HF tissues might have led to the lack of marked inflammatory response to LPS and TNF-, while the lack of macrophages in EpiAlveolar tissues might have impacted the response to Crystalline silica, Amorphous silica, Amiodarone, and LPS given the lack of response in the cytokine/chemokine panel