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Under hypoxia, HIF-1 upregulates PDK1, reinforcing the glycolytic phenotype (238)

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10.1182/blood-2006-02-003681 [DOI] [PMC free article] [PubMed] [Google Scholar] Okada T, Shiono Y, Hayashi H, Satoh H, Sawada T, Suzuki A, Takeda Y, Yano M, Michitaka K, Onji M, & Mabuchi H (2000)

89 Licofelone, characterized as a FLAP inhibitor and also has a weak effect on microsomal prostaglandin E synthase-1 (mPGES-1), developed by Merckle and the partners Alfa Wassermann and Lacer, has reached clinical phase III for the treatment of knee osteoarthritis 90 with several studies successfully completed