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It was shown that 48-h exposure to chromium (VI) (10 M) significantly increased the concentration of cytosolic Ca 2+ level, decreased the concentration of ATP (20 M), or increased the binding of annexin V

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After a closed head injury, ApoE / mice exhibit elevated levels of iron in their brains, suggesting that ApoE / deficiency may increase the risk of oxidative damage to hippocampal tissue ( In vitro studies show that upregulating sestrin2 decreases type I/II collagen and KEAP1 mRNA expression while increasing GPX4 and Nrf2 mRNA levels

N., Jansen, H., Kennedy, R