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For highly hydrophobic toxins such as MMAE, adjusting hydrophobicity through short PEG chains or polar linkers can reduce aggregation

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doi: 10.3389/fnins.2025.1671955 Received 24 July 2025 Revised 10 December 2025 Accepted 16 December 2025 Published 13 January 2026 Volume 19 - 2025 Edited by Fangchen Gong, Shanghai Jiao Tong University, China Reviewed by Al-Shaimaa Faissal Ahmed, Minia University, Egypt John Sieh Dumbuya, Affiliated Hospital of Guangdong Medical University, China Updates Copyright 2026 Li, Wang, Ma, Peng, Wang, Wang, Li and Wang

The search for preventive and therapeutic strategies against diseases caused by MeHg has seen significant effort in the literature (Moniruzzaman et al