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This article is part of the Topical Collection on Diabetes and Obesity Rights and permissions About this article Cite this article Argyrakopoulou, G., Konstantinidou, S.K., Dalamaga, M

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Despite the undeniable possibilities for application of mRNA-based therapeutics clinically and the advances that have been made towards this, there are still existing significant challenges to their widespread application owing to their inherent instability, vulnerability to enzymatic degradation, extraordinary large size and extreme sensitivity to temperature requiring even lower temperatures than conventional vaccines

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