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112 Islet cells shift from a compensatory increase to reduced function and decreased cell mass

While it can be nothing more than speculation because of the small sample size, patients who showed therapeutic effects following glutathione treatment appeared to be younger and did not have diabetes or had mild diabetes

Caution is warranted because animal findings do not reliably map onto what happens in people

the treatment also increased the expression of antioxidant genes, such as Hmox1 , Nqo1 , Cat, and Sod1 , enhanced NRF2 activity, decreased the expression of Nox4 , and attenuated the levels of intracellular reactive oxygen species