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Cell stem cell

518,519,520 Besides, through maintaining the rate of NAD + production and normalizing the NADH/NAD + balance, both pentylenetetrazole (PTZ) and niacin (NA) exhibit neuroprotective properties

This review systematically describes the multi-target mechanisms of SIRT1 in MASLD pathogenesis through its regulation of critical factors, including peroxisome proliferator-activated receptor gamma coactivator 1-, Forkhead Box O, and nuclear factor kappa-light-chain-enhancer of activated B cells, which govern hepatocyte lipid remodeling, mitochondrial quality control, autophagyendoplasmic reticulum stress balance, and Kupffer cell/T cell polarization