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Despite the susceptibility of C-terminal cleavage, using albumin for half-life extension of biologics remains appealing for several reasons

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It is a lipophilic molecule, so it can pass the bloodbrain barrier, exerting its antioxidant and anti-inflammatory actions through reducing the production of reactive oxygen species and inflammatory cytokines, respectively (Kucukgoncu et al

The increased expression of SIRT6 can effectively inhibit the Notch1/Jagged1 signaling pathway, reducing the secretion of pro-inflammatory factors including IL-6 and TNF-, thereby significantly alleviating DKD (Ma et al., 2025)