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While the primary focus of this investigation is the characterization of GpoA, the findings related to AhpD merit detailed consideration

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This dysregulation increases iron storage, promoting M1 polarization (89)

Clinical markers of progression Older age, male sex, higher baseline motor scores and worse baseline cognition have all been linked to worse motor and cognitive outcomes at longitudinal follow-up 141,182,194,195,196 and have been integrated with sleep disorder, presence of depression and various genetic, imaging or CSF biomarkers into clinical predictive scores 182,196
