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Brain Res Rev 67(12):157183 Srinivasana G, Shukla D (2024) Cannabis-derived pharmaceutical products: therapeutic, pharmacokinetic and clinical implications-a comprehensive review

The Lancet Gastroenterology & Hepatology, 9(1), 38-49.

So there is a mechanism by which tryptophan can either get prioritized towards serotonin and melatonin production, or it can get shifted in another direction where we make kind of Rumenic and quinolinic acid, which are associated with pain and inflammation
