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doi: 10.1080/1061186X.2024.2389892 269 AryaPRaghavN

157 MMT exhibits minimal systemic absorption due to its inability to permeate the GI epithelium, ensuring its elimination alongside adsorbed toxins without interfering with normal bowel function

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Kihara Y, et al

L-citrulline supplementation Rationale Oral L-arginine undergoes first-pass metabolism [38% in humans (Castillo et al., 1993)], whereas L-citrulline is converted into L-arginine via the argininosuccinate pathway, in which argininosuccinate synthase (ASS) catalyzes the formation of argininosuccinate from citrulline and aspartate