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Effect of in vitro generation of oxygen free radicals on t cell function in young and old rats

2017 Feb 28;8(9):14835-14846

In the context of CHD, these processes contribute to the recruitment of inflammatory cells to the arterial wall, accelerate the progression of atherosclerotic plaques, and increase the risk of plaque rupture and subsequent cardiovascular events (125)

Taken together our data indicate that mitapivat significantly ameliorates the membrane mechanical cohesion and stability of 4.2 / mouse RBCs
