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Prevention: Use low dead space (LDS) syringes when dosing under 15 units

Specifically, AX upregulated peroxisome proliferator-activated receptor- coactivator 1-alpha (PGC-1) and mitochondrial transcription factor A (TFAM), key regulators of mitochondrial DNA replication and transcription, as well as oxidative phosphorylation (OXPHOS) complex proteins, resulting in increased mitochondrial DNA content and ATP production