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In the STEP 1 trial, semaglutide led to an average 14.9% reduction in body weight over 68 weeks , far outperforming placebo (NEJM study on semaglutide for weight loss)

(105) found that FP cell-free supernatant exerts non-butyrate-dependent anti-inflammatory effects by reducing colonic TNF-/IL-12 and increasing serum IL-10

Moreover, the glucagon receptor component is the game-changer

Choose semaglutide when Semaglutide is often the better starting point for users who are new to GLP-1 agonists, have concerns about side effects, prefer a simpler dose escalation schedule, or need a peptide with longer real-world track record data