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The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress

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[DOI] [PubMed] [Google Scholar] 42.Fraga CG, Motchnik PA, Shigenaga MK, Helbock HJ, Jacob RA, Ames BN

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This broad therapeutic window suggests the peptide operates differently from conventional medications with narrow dosing requirements

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In this process, excessive degradation of aggrecan and Col II leads to NP dehydration and resorption and a decline in the ability of the cells to resist mechanical loading, thus contributing to IDD progression 92,93

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