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The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress

[DOI] [PubMed] [Google Scholar] 42.Fraga CG, Motchnik PA, Shigenaga MK, Helbock HJ, Jacob RA, Ames BN

This broad therapeutic window suggests the peptide operates differently from conventional medications with narrow dosing requirements

In this process, excessive degradation of aggrecan and Col II leads to NP dehydration and resorption and a decline in the ability of the cells to resist mechanical loading, thus contributing to IDD progression 92,93
