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These autoantibodies may also be used as an enrichment factor in clinical trials to identify subjects in the pre-symptomatic stages of the disease with a high risk of disease progression to symptomatic

The second or further protein may be a (selectable) marker protein that allows for the identification, selection and/or screening for cells containing the expression construct

Certain glycosides cause severe histopathological lesions including vacuolization and necrosis in adult fish (Zhong et al., 2019), and aurantio-obtusin (AO) drives inflammation-driven hepatotoxicity by activating NLRP3 inflammasomes ( Thus, zebrafish models provide a comprehensive and integrative framework for hepatotoxicity assessment, effectively complementing their role in efficacy screening

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