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and Li T., Pharmacology of Bile Acid Receptors: Evolution of Bile Acids From Simple Detergents to Complex Signaling Molecules, Pharmacological Research 104 (2016): 921

doi: 10.3969/j.issn.1672-5123.2010.06.034 9
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Therefore it is often difficult to mimic the nanoscale extracellular matrix properties of some tissues