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10.1016/j.clnesp.2022.01.038 226 ZeebareeB
M.GhenovF.SunaseeR.et al (2017)
A 2025 meta-analysis (Li et al.) pooling 7 RCTs (n=456) confirmed the finding with a standardised mean difference of 0.72 for wrinkle reduction (95% CI 1.02 to 0.42
Hence, inhibition of ACE enzyme will lead to lower generation of hematopoietic stimulant, ATII, and also parallel accumulation of hematopoietic inhibitor, AcSDKP
