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ACS Nano 2020, 14 (1), 347359

Several genes like apolipoprotein (APOE4), presenilin-2 (PSEN2), presenilin-1(PSEN1), amyloid-beta precursor protein (APP), microtubule-associated protein tau (MAPT), etc., are also associated with a higher or lower risk of sporadic early or late-onset of AD (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 125.Avgerinos K.I., Spyrou N., Mantzoros C.S., Dalamaga M

[2] In all these tissues, a constant supply of NADPH is required to sustain reductive biosynthesis and/or to counteract reactive oxygen species (ROS), which can damage sensitive cellular structures such as DNA, membrane lipids, and proteins