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This approval provides patients with a new treatment option for the symptoms associated with advanced heart failure, said Bram Zuckerman, M.D., director of the Office of Cardiovascular Devices in the FDAs Center for Devices and Radiological Health

they are responding

Dosing typically begins at a lower dose, suggested initiation of 20 units (0.2 mL) weekly for the first 4 weeks, then escalates according to a titration schedule: Weeks 14: Inject 20 units (0.2 mL) one time per week Weeks 58: Inject 40 units (0.4 mL) one time per week Weeks 912: Inject 70 units (0.7 mL) one time per week Weeks 1316: Inject 90 units (0.9 mL) one time per week Weeks 1720: Inject 120 units (1.2 mL) one time per week Week 21+: Inject 140 units (1.4 mL) one time per week Dosing may deviate from this pattern to accommodate patient-specific needs

Potential Benefits of AOD-9604 Fat Breakdown and Body Composition The core mechanism of AOD-9604 is dual: it stimulates lipolysis (the breakdown of stored fat into free fatty acids the body can use for energy) while simultaneously inhibiting lipogenesis (the conversion of excess calories into new fat stores)