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The degree of lifespan reduction was greatest in the glp-1(-) mutant, and least in the short-lived mog-3(-) mutant (Supplementary Fig
Collectively, this evidence indicates that KIN-19 is essential for metabolic flexibility, with its absence mimics a permanent fasting state that severely impairs the animals ability to adapt to nutrient changes
Study Results (2003 Cross-over Method) A similar study in 2003 used a cross-over method and involved 86 patients with spermogram disorders
