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Oxidative stress and copper-dependent enzymes Copper is a critical cofactor for enzymes involved in oxidative stress regulation

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MEOS uses a different enzyme (Cytochrome P450 2E1 - CYP2E1) to metabolize ethanol, but still creates toxic acetaldehyde

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On the inflammatory front, curcumin inhibits microglial activation and downregulates the expression of inflammatory enzymes and cytokinesfor instance, it suppresses iNOS and COX-2 induction and lowers levels of TNF- and other interleukins in activated glial cells (72)

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