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Description
Carotenoids may upregulate the activity of antioxidant enzymes, mainly via the activation of the Nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent pathway (Kaulmann and Bohn 2014)
Although the cell death mechanism of RPE, which is susceptible to oxidative stress, remains controversial, ferroptosis has been recently recognized as a primary mode of RPE cell death (81)
Antimicrob Agents Chemother 42:17781782 Mueller LA, Goodman CD, Silady RA, Walbot V (2000) AN9, a petunia glutathione S-transferase required for anthocyanin sequestration, is a flavonoid-binding protein
Walters et al., 2011
