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Using the mandibular condyle of 2 day old ICR mice, Maor et al showed that these condyles, which resemble the epiphyseal plates of the long bones, contain IGF-1 and high affinity IGF-1 receptors also in the chondroprogenitor cell layers, which enables them to respond to IGF-1 in vitro

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Extracellularly, HMGB1 can regulate inflammation and immune response

Defined composition: Fixed amounts of each component to simplify comparative and combination studies
