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I honestly dont think it really matters which route you choose

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A 12-week study involving supplementation with 430 mg or 860 mg of annatto TT showed significant decreases in urine N-terminal telopeptide (NTX) levels (a bone resorption marker), circulating receptor activator of nuclear factor kappa-B ligand (RANKL) levels, and RANKL/osteoprotegerin ratios, as well as an increase in bone alkaline phosphatase/NTX ratio (a bone formation marker) compared to a placebo control group (37)

These findings reveal that vitamin B6 is a nonredundant cofactor in T-cell immunometabolism, and modulating vitamin B6 metabolic pathways could offer a novel immunotherapeutic approach to boost antitumor responses