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Lastly, given the genomic focus of our study, the uncharacterized candidate genes here identified will inherently require further experimental testing to explore their mechanistic role in the aetiology of disease

GLUD1mediated production of alpha-ketoglutarate (-KG) and the accumulation of ROS trigger migration and invasion by inducing the expression of Snail (25)

Deficiency of parkin suppresses melanoma tumor development and metastasis through inhibition of MFN2 ubiquitination

That means at least 12-16 weeks at or near the maximum tolerated dose