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Administer vitamin B12, 1 mg intramuscularly, 1 week prior to the first dose of ALIMTA and every 3 cycles thereafter

Accordingly, neurodegenerative changes are present elsewhere in the nervous system, such as other regions of cerebral cortex, the hippocampus, and cerebellum [19]

Though it did not show significant benefit 6 months post-TBI, administration in combination with other drugs may support its utility (Pan et al., 2019)

therefore, it is advised that patients older than 50 years and vegans or strict vegetarians should consume foods fortified with vitamin B12 or take vitamin B12 supplements to avoid vitamin B12 deficiency