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Oligodendrocytes are particularly vulnerable to cuprizone-induced mitochondrial dysfunction 7 , resulting in apoptosis 1 and subsequent loss of myelin 4

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However, two studies reported an increase of 1 subunit mRNA expression (34, 64), one study revealed an increase of 5 subunit mRNA (34), one study observed an increase of the GABA A receptor 1 subunit protein (72), and one study demonstrated no change of the 4 receptor subunit (80)

Abstract Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, which is characterized by inattention, impulsivity and hyperactivity