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IGFBP-3 is regulated mainly by GH but also to some degree by IGF-1
A study by Yang et al (117), using a rat acute myocardial infarction model and in vitro CF experiments, demonstrated that medium-to-high doses of TSA notably improved left ventricular function, reduced collagen deposition and downregulated TGF-1, Col1a1, Col3a1 and -SMA expression while upregulating miR-29b (117)
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