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Importantly, multiple targets do not mean that research related to single chemical metabolites should be ignored in TMMM (Zhao et al., 2018), validated that gut microbiota transformed albiflorin to benzoic acid, which is a key intestinal metabolite that can cross the bloodbrain barrier and inhibit brain D-amino acid oxidase, thereby improving brain function and exerting antidepressant effects

It keeps the area clean, lowers the risk of infection, calms irritation, fosters healing, and helps the skin repair itself properly

doi: 10.1016/j.neuroscience.2013.04.017 210 LiWWPenderisJZhaoCSchumacherMFranklinRJ

Longer cycles should include careful self-monitoring and ideally involve periodic blood work including copper levels