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127 In addition to the cumbersome nature of the masks, CPAP treatment is associated with dry mouth, nasal discharge, congestion, bloody nose, headache, sore throat, hoarse voice, and reduced sense of smell

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have shown that Atp7b knockout mice exhibit reduced levels of lipoylated enzymes and FeS cluster proteins compared to wild-type mice, 2 reminiscent of the cellular phenotype induced by Cu ionophores (Fig

Finally, the fermentation was scaled up in a 5-L fermentor, and the highest titer and yield were improved to 5680 mg/L and 45.13 mg/g, respectively, by optimizing the addition conditions of amino acids (40 mM added after 40 h)