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Tests in bacteria, cells, and mice all came back negative, suggesting the compound does not pose carcinogenic risk through DNA damage mechanisms

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The compact conformation of EBOV polymerase we obtained here may also represent a specific state in the catalytic cycle, which might be adopted by other nsNSVs as well

18,19 While PDE-5 inhibitors have revolutionized the management of ED, the remainder of this review will focus on alternative treatment options and potential treatment strategies in the setting of failed PDE-5 inhibitor therapy or contraindications