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Our previous study revealed that lenvatinib treatment reduced carnitine content and the expression of carnitine-related and oxidative phosphorylation (OXPHOS) proteins in the skeletal muscle of rats

Dialysis-associated carnitine deficit, in turn, has been linked to a number of symptoms seen in uremic patients, including fatigability, cardiomyopathy, anemia, and skeletal muscle weakness (Eknoyan et al., 2003)

Meanwhile, fumaric acid is a key constituent of the Krebs cycle, fueling this process even more
