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Description
By binding to the IGF-1 receptor (IGF1R), IGF-1 initiates the phosphorylation of phosphatidylinositol 2-phosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), which activates downstream signaling pathways involving AKT and the mammalian target of rapamycin (mTOR)

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Subsequently, 1 M dihydroethidium (DHE) was added to the medium and further incubated for 30 min

doi: 10.3233/JAD-2005-7107
