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Bartels, T

MDM2 overexpression is a common feature in lung cancers and the MDM2-p53 loop contributes to chemotherapeutic resistance in human malignancies (47, 48)

According to studies on rodents, high levels of cytokines might be the cause of the characteristic symptoms of behaviour present in both development and adulthood in ASD (Depino, 2013)

Here we developed a sphingolipid-derived PTX nanovesicle (paclitaxome) via covalently conjugating PTX to sphingomyelin, which improved pharmacokinetics and enhanced efficacy in metastatic triple-negative breast cancer and pancreatic cancer female mice and reduced myelosuppression