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doi: 10.1186/s12935-019-0938-3 74 AkslenLAAngeliniSStraumeOBachmannIMMolvenAHemminkiKet al

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It acts as a non-selective melanocortin receptor agonist with the following binding profile (approximate Ki values): MC1R : ~0.67 nM (highest affinity, melanogenesis) MC4R : ~6.6 nM (appetite suppression, sexual function) MC3R : ~34 nM (energy balance) MC5R : ~46 nM (exocrine gland function) This broad receptor profile produces multiple physiological effects