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A separate 2025 narrative review confirmed three total published human pilot studies and noted that no major adverse events were reported across those pilots [15]
In advanced liver cirrhosis, IGF-I serum levels decrease as a result of diminished hepatocellular biosynthetic function and progressive loss of GH receptors on hepatocytes [13, 14]
8 (6), e0458
They conclude that a larger study population is necessary to evaluate rapid-acting insulin efficacy in this population better
