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Mechanistic studies reveal that acetyl-L-carnitine enhances cholinergic neurotransmission by increasing acetylcholine synthesis and release, upregulates nerve growth factor (NGF) expression, improves mitochondrial membrane potential and respiratory function in neurons, reduces oxidative damage to neural lipids and proteins, and modulates synaptic plasticity and neurotransmitter receptor function

Data are presented as mean (SD) and mean difference (95% CI)

The proposed mechanism for cell damage following ischemia is oxidative stress and inflammation

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