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When applied or administered correctly, it penetrates deep into the skin to stimulate repair and regeneration at a cellular level
Proliferation and differentiation of ESCs are also influenced in opposite ways through IIS or Tgf-signalling
Here we report the design of a fracture-targeted peptide comprised of a payload that binds and activates the parathyroid hormone receptor (PTHR1) and is linked to a targeting ligand comprised of 20 D-glutamic acids (D-Glu 20 ) that directs accumulation of the payload specifically at fracture sites
doi: 10.1172/JCI176345
