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69 Thirdly, during the DPN, excess saturated fatty acids (SFAs) and hyperglycemia depolarize mitochondrial membranes and generate ROS, 70 which eventually produce mitochondrial dysfunction and Schwann cells (SCs) apoptosis
Chew EY, Clemons TE, Agrn E, et al
Moreover, various mechanisms of transport pathways across BBB, several novel strategies, and alternative routes by which drugs can be properly delivered into CNS are also discussed
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