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Good patient-centred decision making around the use of dietary supplements requires multidisciplinary care, involving oncologists, integrative medicine providers, clinical pharmacists, dietitians and nursing to monitor and mitigate risk as well as to fully document all supplement uses and be aware how they may interact with conventional therapy (239)

Abnormalities in mitochondrial complex I activity increase the aggressiveness of human breast cancer cells (69)

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In the case of enzymopathies, this is not generally necessary because a loss of enzyme activity is in itself a good readout of pathogenicity