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Lactate has been reported to induce protective autophagy in retinal pigment epithelial cells, mitigating oxidative stress and cell death through AMPK activation (101,145)

In the BLOOM trial, patients treated with lorcaserin achieved highly significant and absolute weight loss in 1 year, and continuous treatment with lorcaserin over 2 years helped two-thirds of the patients maintain a weight loss of 5% or greater [83]

Main results: LT restored estrous cyclicity, lowered the LH/FSH ratio and serum testosterone levels, and improved insulin sensitivity

Modulation of the fumarases of Escherichia coli in response to oxidative stress